What is the function of interleukin 23?

What is the function of interleukin 23?

IL-23 functions in innate and adaptive immunity, and is a key cytokine for promoting inflammatory responses in a variety of target organs. The most important function ascribed to IL-23 is its role in the development and differentiation of effector Th17 cells via activation of STAT3.

Which cells produce IL-23?

Innate lymphoid cells and γδ T cells also produce IL-23. B cells produce IL-23 through B cell antigen receptor signaling. Secretion is stimulated by an antigen stimulus recognised by a pattern recognition receptor. IL-23 imbalance and increase is associated with autoimmune diseases and cancer.

Do Th17 cells produce IL-23?

In response to inflammatory stimuli, dendritic cells produce IL-23 and IL-1β, which induce development of Th17 cells that produce IL-17, IL-22, IL-17F, and other proinflammatory cytokines.

Do dendritic cells produce IL 17?

(A) Inflammatory cytokines including interleukin (IL)-23 and IL-6 produced by cells of the innate immune system such as dendritic cells and macrophages facilitate the differentiation of Th17 cells.

What is an IL-23 inhibitor?

Biologics are protein-based medications that target specific parts of the immune system. IL-23 inhibitors target a type of cytokine called IL-23. Cytokines are a class of proteins that help transmit signals from one cell to another. IL-23 plays a role in a signaling pathway that triggers inflammation.

How is IL-23 produced?

IL-23 is produced primarily by activated macrophages and dendritic cells (DCs). It expands Th17 cells and maintains their phenotype such as their cytokine production including IL-17A, which is their major effector molecule15.

Is IL-23 anti inflammatory?

Interleukin-23 (IL-23) is a pro-inflammatory cytokine composed of two subunits, IL-23A (p19) and IL-12/23B (p40), the latter shared with Interleukin-12 (IL-12).

Is Humira an IL-17?

MADRID — In patients with psoriatic arthritis, the combined end point of skin clearance and reduced disease activity was better with ixekizumab (Taltz, Eli Lilly), an interleukin (IL)-17 inhibitor, than with adalimumab (Humira, AbbVie), a TNF inhibitor, early results from the SPIRIT-H2H (NCT03151551) trial show.

Are interleukins antibodies?

Interleukins are a diverse, multifunctional group of proteins that carry out communication between various immune cells and control their gene expression. They manage the intensity and magnitude of an inflammatory response, and control differentiation, proliferation, and secretion of antibodies.