What is SLUG transcription factor?
SNAI2 (Slug) is also a zinc‐finger transcription factor that has activities similar to Snail, including E‐cadherin transcriptional repression and anti‐apoptotic activity, and it plays a crucial role in organogenesis and neuralization.
What is Snail transcription factor?
Snail is a family of transcription factors that promote the repression of the adhesion molecule E-cadherin to regulate epithelial to mesenchymal transition (EMT) during embryonic development.
What is SLUG protein?
The SNAI2 gene (often called SLUG) provides the instructions for making a protein called snail 2. Snail 2 belongs to the snail protein family, which plays a role in the formation of tissues during embryonic development.
What is Twist gene?
The TWIST1 gene provides instructions for making a protein that plays an important role in early development. This protein is a transcription factor, which means that it attaches (binds) to specific regions of DNA and controls the activity of particular genes.
What does the Slug gene do?
SLUG (the protein product of SNAI2) is a member of the Snail family of zinc-finger transcription factors (Nieto, 2002). It is involved in the regulation of cell migration during embryogenesis and in tumour cell invasion and migration (Cobaleda et al, 2007).
Is twist an oncogene?
What causes EMT?
EMT has been shown to be induced by androgen deprivation therapy in metastatic prostate cancer. Activation of EMT programs via inhibition of the androgen axis provides a mechanism by which tumor cells can adapt to promote disease recurrence and progression.
Is Smad a transcription factor?
Trimers of two receptor-regulated SMADs and one co-SMAD act as transcription factors that regulate the expression of certain genes.
Is twist a transcription factor?
Twist, the basic helix-loop-helix transcription factor, is involved in the process of epithelial to mesenchymal transitions (EMTs), which play an essential role in cancer metastasis. Overexpression of Twist or its promoter methylation is a common scenario in metastatic carcinomas.
Where are transcription factors synthesized?
Nuclear localization In eukaryotes, transcription factors (like most proteins) are transcribed in the nucleus but are then translated in the cell’s cytoplasm. Many proteins that are active in the nucleus contain nuclear localization signals that direct them to the nucleus.
What type of protein does the Twist 1 gene code for?
Twist-related protein 1 (TWIST1) also known as class A basic helix–loop–helix protein 38 (bHLHa38) is a basic helix-loop-helix transcription factor that in humans is encoded by the TWIST1 gene….Twist-related protein 1.
What happens during EMT?
The EMT process involves the disruption of cell–cell adhesion and cellular polarity, remodeling of the cytoskeleton, and changes in cell–matrix adhesion. It is associated with improvement in migratory and invasive properties.
What is the function of the snail family of transcription factors?
The Snail family of transcription factors are repressors that play a central role in the epithelial-mesenchymal transition, a process that occurs during cancer progression. Snail and Slug members are direct repressors of E-cadhe …
Do snails and slugs have inappropriate expression in bladder carcinoma?
These data demonstrate that twist, snail and slug have inappropriate expression in bladder carcinoma and that this may play a part in the progression of human bladder carcinoma. Expression of transcription factors snail, slug, and twist in human bladder carcinoma
Are slug and snail direct repressors of E-cadhe cells?
Snail and Slug members are direct repressors of E-cadhe … The transcription factors Slug and Snail act as repressors of Claudin-1 expression in epithelial cells Biochem J. 2006 Mar 1;394(Pt 2):449-57.doi: 10.1042/BJ20050591.
Is Claudin-1 a downstream target gene of snail family factors in epithelial cells?
Significantly, in invasive human breast tumours, high levels of Snail and Slug correlated with low levels of Claudin-1 expression. Taken together, these results support the hypothesis that Claudin-1 is a direct downstream target gene of Snail family factors in epithelial cells.