What is precedex drip used for?
Precedex is indicated for sedation of initially intubated and mechanically ventilated patients during treatment in an intensive care setting. Precedex should be administered by continuous infusion not to exceed 24 hours.
Does precedex prevent withdrawal seizures?
Dexmedetomidine lacks any GABA activity. It does not prevent seizure associated with severe alcohol withdrawal.
What is the mechanism of action of precedex?
Dexmedetomidine is a specific and selective alpha-2 adrenoceptor agonist. By binding to the presynaptic alpha-2 adrenoceptors, it inhibits the release if norepinephrine, therefore, terminate the propagation of pain signals.
How do you treat precedex withdrawal?
Clonidine is an effective treatment option for dexmedetomidine withdrawal. Given the prolonged duration of the sedative agent, clonidine may be initiated at lower doses (0.1 mg), which can be safely used in patients with lower systolic blood pressure.
Does precedex affect heart rate?
Patients who receive dexmedetomidine and develop a greater than 30% decrease in heart rate may be at high risk for severe bradycardia leading to pulseless electrical activity. We urge caution when using dexmedetomidine, especially in patients with significant cardiac disease.
Why can precedex only be used for 24 hours?
The FDA states that if used for >24 hours, dexmedetomidine can cause tolerance and tachyphylaxis. The FDA also states that prolonged exposure can cause a dose-related increase in adverse events such as acute respiratory distress syndrome (ARDS), respiratory failure and agitation.
Can you give Ativan and Precedex together?
Interactions between your drugs Using LORazepam together with dexmedetomidine may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination.
Can you get addicted to Precedex?
9.3 Dependence. The dependence potential of Precedex has not been studied in humans.
Does Precedex cause bradycardia?
It is a distinctive sedative because it does not cause respiratory depression, but it may cause hypotension and bradycardia.
Does propofol cause bradycardia?
Propofol-induced bradycardia is common, and in some instances life-threatening (1–3). Administration of atropine with propofol may block parasympathetic activation, preventing bradycardia (4).
How long does it take to wean off of precedex?
Although there is no standard protocol for discontinuing dexmedetomidine in our unit, patients are typically weaned at a rate of 0.1–0.4 μg/kg/hr every 8–24 hours based on duration and dose of the infusion at the moment of discontinuation.
Why is dexmedetomidine better than clonidine?
Dexmedetomidine is 8 times more specific for α2 receptors than clonidine and the improved specificity for the α2 adrenoreceptors, especially for the 2A subtype may make it to be a much more effective sedative than clonidine.  Our finding of dexmedetomidine treated patients is in concurrence with previous studies.
Is dexmedetomidine safe in patients with bradycardia?
Patients who receive dexmedetomidine and develop a greater than 30% decrease in heart rate may be at high risk for severe bradycardia leading to pulseless electrical activity. We urge caution when using dexmedetomidine, especially in patients with significant cardiac disease. Publication types
Can dexmedetomidine be used to treat alcohol withdrawal without supplemental benzos?
More research is needed: No studies have used Dexmedetomidine to treat alcohol withdrawal without supplemental benzos ∗ Albertson T, Chenoweth J, Ford J, et. al. Is it prime time for alpha2-adrenocepter agonists in the treatment of withdrawal syndromes? J Med Toxicol. 2014; 10 (4):369-381.
Which medications are used in the treatment of alcohol withdrawal syndrome?
∗ Crispo A, Daley M, Pepin J, Harford P, Brown C. Comparison of clinical outcome in nonintubated patients with severe alcohol withdrawal syndrome treated with continuous-infusion sedatives: Dexmedetomidine versus benzodiazepines. Pharmacotherapy. 2014; 34 (9):910-917.
What is the effect of dexmedetomidine on sedation in alcoholics during ERCP?
∗ Mazanikov M, Udd M, Kylanpaa L, et. al. Dexmedetomidine impairs success of patient-controlled sedation in alcoholics during ERCP: A randomized, double blind, placebo-controlled study. Surg Endosc. 2013; 27 (6):2163-2168.