What is platensimycin (PTM)?

What is platensimycin (PTM)?

This review begins with the pioneering discovery and biological activities of platensimycin (PTM) and platencin (PTN), two antibacterial natural products isolated from Streptomyces platensis.

How does platensimycin 17 kill bacteria?

The antibiotics currently used kill bacteria by one of four established mechanisms; however, platensimycin 17 uses a unique mechanism of action – inhibition of cellular lipid biosynthesis <2006NAT358>. This is the first new mechanism of antibiotic action discovered in over 40 years.

What is platensimycin (12)?

Platensimycin (12 ), an ent -kaurene diterpenoid with the degraded A ring, was first discovered by the Merck research group by employing an antisense differential sensitivity screening strategy. The first total synthesis of PTM was reported by Nicolaou et al. [40] in the same year when platensimycin was discovered.

How does platensimycin interact with dodecanoic acid?

This can clearly be seen in Figures 6 (a) and 6 (b) in which the structures of ecFabF complexed with dodecanoic acid and platensimycin have been overlaid. Platensimycin is a recently discovered natural product isolated from Streptomyces platensis that inhibits the KAS I and KAS II enzymes, binding more tightly to the acyl-enzyme form of the enzyme.