What is Enterohepatic drug recycling?
Enterohepatic recirculation is the process by which biliary excreted drug is reabsorbed in the intestine instead of being removed from the body. This can result in a lagging secondary absorption process and increases in drug exposure.
What is the purpose of enterohepatic circulation?
Enterohepatic circulation of drugs describes the process by which drugs are conjugated to glucuronic acid in the liver, excreted into bile, metabolized back into the free drug by intestinal bacteria, and the drug is then reabsorbed into plasma.
What causes increased enterohepatic circulation?
Certain factors present in the breast milk of some mothers may also contribute to increased enterohepatic circulation of bilirubin (breast milk jaundice). β-glucuronidase may play a role by uncoupling bilirubin from its binding to glucuronic acid, thus making it available for reabsorption.
How does biliary recycling affect the elimination half life of drugs?
EHC of a compound/drug occurs by biliary excretion and intestinal reabsorption, sometimes with hepatic conjugation and intestinal deconjugation. EHC leads to prolonged elimination half-life of the drugs, altered pharmacokinetics and pharmacodynamics.
How does enterohepatic circulation affect bioavailability?
Intestinal reabsorption to complete the enterohepatic cycle may depend on hydrolysis of a drug conjugate by gut bacteria. Bioavailability is also affected by the extent of intestinal absorption, gut-wall P-glycoprotein efflux and gut-wall metabolism.
What is enterohepatic circulation of bile?
The term enterohepatic circulation (EHC) denotes the movement of bile acid molecules from the liver to the small intestine and back to the liver. Bile acids traverse the hepatocyte and are actively secreted into canalicular bile, completing the enterohepatic cycle.
Which of the following is the best description of enterohepatic circulation?
Which of the following statements best describes the enterohepatic circulation? It is the recycling of bile between intestine and liver. What is the main physiological function of the stomach? To disinfect the food.
Where does enterohepatic circulation occur?
How does fiber interfere with the enterohepatic circulation of bile?
Evidence suggests that soluble fiber hinders the reabsorption of bile salts in the small intestine into enterohepatic circulation. Bile recirculation is normally highly efficient but soluble fiber traps bile salts in the gut and inhibits reabsorption.
Does rifampicin undergo enterohepatic cycling?
Considering the clinical pharmacokinetics of rifampicin, which enters the enterohepatic circulation and undergoes subsequent hepatic accumulation, it may be especially beneficial as an antitumor agent targeting hepatobiliary tumors.
What affects enterohepatic circulation?
What is the importance of the enterohepatic circulation quizlet?
1) The enterohepatic circulation reabsorbs bile salts in the distal portion of the small intestine (ileum).