What is CD66?
CD66, a member of the carcinoembryonic antigen family, is known to be expressed on cells of myeloid and monocytic origin and has also been demonstrated on blasts from patients with B-lineage acute lymphoblastic leukaemia.
What is a marker for neutrophils?
Markers for neutrophil maturation Among these are CD15, CD11b, CD16, and CD10, which immature, differentiating neutrophils begin to express. For mature, circulating neutrophils, a phenotype of CD16hi, CXCR2hi, CXCR4low, and CD62Lhi has been reported.
Do neutrophils express CD11b?
CD11b is an immunological marker for early detection of neonatal sepsis [29] and a cell surface antigen of neutrophil [30]. Its expression on neutrophil cell surface, however, increases substantially within a few minutes after the cell comes into contact with bacteria or endotoxins [31].
What is CD16 a marker for?
CD16-mediated activation of NK cells is a potent signal for inducing ADCC and is a major mechanism of anti-tumor efficacy by therapeutic antibodies to tumor antigens.
What does CD11b stain?
CD11b is expressed on the surface of many leukocytes including monocytes, neutrophils, natural killer cells, granulocytes and macrophages, as well as on 8% of spleen cells and 44% of bone marrow cells. Functionally, CD11b regulates leukocyte adhesion and migration to mediate the inflammatory response.
What is CD11b a marker for?
. CD11b (Mac-1): a marker for CD8+ cytotoxic T cell activation and memory in virus infection.
What does neutrophil elastase do?
Neutrophil elastase is secreted by neutrophils during inflammation, and destroys bacteria and host tissue. It also localizes to neutrophil extracellular traps (NETs), via its high affinity for DNA, an unusual property for serine proteases.
What cell expresses CD16?
CD16 is involved in antibody-dependent cell-mediated cytotoxicity and is expressed on large granular lymphocytes (LGLs) of both NK- and T-cell types. Approximately 15–20% of the peripheral blood lymphocytes and a much smaller fraction (5%) of bone marrow lymphocytes express dim CD16.
Do neutrophils express CD16?
CD16 is a low affinity Fcγ receptor, which could activate antibody-dependent process like phagocytosis in neutrophils and other phagocytes [37]. It is expressed on neutrophils during the maturation.
What is the role of CD11b?
CD11b modulates several key biological functions in innate immune cells, including cell adhesion, migration, and phagocytosis.
What cells are CD15 positive?
CD15 is a haemopoietic differentiation antigen expressed on most terminally differentiated myeloid cells including granulocytes, eosinophils, mast cells, monocytes/macrophages, and Langerhans’ cells. It is not expressed in red cells, platelets and lymphocytes (2).