What are human CD34 cells?
CD34 is a glycosylated transmembrane protein and represents a well-known marker for primitive blood- and bone marrow-derived progenitor cells, especially for hematopoietic and endothelial stem cells.
What is CD34 in bone marrow?
CD34 is a transmembrane phosphoglycoprotein, first identified on hematopoietic stem and progenitor cells. Clinically, it is associated with the selection and enrichment of hematopoietic stem cells for bone marrow transplants.
What are CD34 negative cells?
This is for hematopoietic reconstitution in patients with higher body weights. Interestingly, literature reports show that CD34- (CD34 negative) cell population also possesses the potential to reconstitute the bone marrow & in a certain phase, converts them into CD34+ phenotype.
What are CD34+ progenitor cells?
Hematopoietic stem cells (HSC) possess multipotentiality, enabling them to self-renew and also to produce mature blood cells, such as erythrocytes, leukocytes, platelets, and lymphocytes. CD34 is a marker of human HSC, and all colony-forming activity of human bone marrow (BM) cells is found in the CD34+ fraction.
Why is CD34 important?
CD34 is a membrane protein that aids cells in cell-cell adhesion. Although little is known about its function, CD34 is an important marker for hematopoietic stem cells (HSCs), muscle satellite cells, and endothelial cells.
What is CD117 positive?
Other mesenchymal tumors that were variably CD 117 positive included clear cell sarcoma (7 of 15), metastatic melanoma (9 of 25), and malignant fibrous histiocytoma (1 of 20). These results indicate that CD117 is a specific marker for GIST among tumors that occur in the GI tract and adjacent regions.
What does CD117 positive mean?
When a tumor biopsy tests positive for the biomarker CD117, the diagnosis is narrowed to two potential conclusions: renal oncocytoma, a benign kidney tumor that is not dangerous, and chromophobe renal cell carcinoma, a form of kidney cancer.
What is a CD34 positive cell?
CD34 is a transmembrane glycoprotein expressed on early lymphohematopoietic stem cells, progenitor cells, and endothelial cells. Also, embryonic fibroblasts and some cells in fetal and adult nervous tissue are CD34-positive.
What are CD117 cells?
The CD117 protein is a transmembrane, tyrosine kinase growth factor receptor that is the product of c-kit gene expression. It is present in a variety of normal human cell types, including breast epithelium, germ cells, melanocytes, immature myeloid cells, and mast cells.
What does CD117 negative mean?
CONCLUSION: CD117-negative KIT mutated GISTs account for approximately 6% of the gastrointestinal mesenchymal tumors. Tumor recurrence or distant metastasis correlates to both the KIT mutations at codons 557/558 and the mitotic counts, but not to the tumor size.