How do you synthesize ranitidine?

How do you synthesize ranitidine?

Ranitidine, N[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N′-methyl-2-nitro-1,1-ethendiamine (16.2. 8), is synthesized from furfuryl alcohol, which undergoes aminomethylation reaction using dimethylamine and paraform, which form 5-(dimethylaminomethyl)furfuryl alcohol (16.2. 6).

Which of the following is starting material for synthesis of ranitidine?

45 5-(Chloromethyl)furfural (CMF) has been proposed as a building block for synthesizing ranitidine (1), a drug currently used to treat peptic ulcer and gastroesophageal reflux disease.

What is ranitidine hydrochloride chemical formula?

Ranitidine hydrochloride | C13H23ClN4O3S – PubChem.

What is ranitidine hydrochloride?

BACKGROUND: Ranitidine is a histamine-2 blocker, which decreases the amount of acid created by the stomach. Prescription ranitidine is approved for multiple indications, including treatment and prevention of ulcers of the stomach and intestines and treatment of gastroesophageal reflux disease.

What is imidazole used for?

Imidazole is used to elute tagged proteins bound to nickel ions attached to the surface of beads in the chromatography column. An excess of imidazole is passed through the column, which displaces the His-tag from nickel coordination, freeing the His-tagged proteins.

How is ranitidine metabolized?

Since Ranitidine Tablets is excreted primarily by the kidney, dosage should be adjusted in patients with impaired renal function. (see DOSAGE AND ADMINISTRATION). Caution should be observed in patients with hepatic dysfunction since Ranitidine Tablets is metabolized in the liver.

Who manufactures ranitidine?

Ranitidine products have been available since the 1980s. Zantac is a brand name for the H2 receptor drugs manufactured by GlaxoSmithKline.

Which derivative is ranitidine?

Ranitidine is a histamine type 2 receptor antagonist (H2 blocker) which is widely used for treatment of acid-peptic disease and heartburn.

Why ranitidine is banned?

The USA, the European Union and Australia prohibit sales of this popular drug because the ranitidine molecule can break down into a potent carcinogen called N-Nitroso-dimethylamine or NDMA.

What company manufactures Zantac?

Pfizer received approval to market an over-the-counter version of Zantac from the Food and Drug Administration (FDA) in 2004. Pfizer was the primary manufacturer of the drug for years. Sanofi-Aventis U.S. now owns the rights to Zantac.

How toxic is imidazole?

Hazard statement(s) H302 Harmful if swallowed. H314 Causes severe skin burns and eye damage. H360 May damage fertility or the unborn child.

What is the molecular formula for ranitidine hydrochloride?

Ranitidine hydrochloride PubChem CID 3033332 Structure Find Similar Structures Chemical Safety Laboratory Chemical Safety Summary (LCSS Molecular Formula C13H23ClN4O3S Synonyms ranitidine hydrochloride Ranitidine HCL

How to prepare ranitidine hydrochloride from seeds?

In the preferred process according to the invention, the ranitidine hydrochloride is prepared in situ in the solvent mixture by adding hydrochloric acid to a solution of the free base in the solvent mixture, in the presence of the seed crystals. EP0626381A1 – Preparation of form 1 ranitidine hydrochloride – Google Patents

What is the Canadian patent number for ranitidine hydrochloride form 2?

The preparation and characteristics of ranitidine hydrochloride Form 2, which is the commercially marketed form, are described in Canadian Patent no. 1,202,638 Crookes, assigned to Glaxo Group Limited, and issued April 1, 1986.

What is the assignee title for ranitidine hydrochloride?

Assignee Title DE4341310A1(en) * 1993-12-03 1995-06-08 Hexal Pharma Gmbh Tablet or capsule containing stable ranitidine hydrochloride Form 1 CA2120874E(en) * 1994-04-08 2002-01-08 Keshava Murthy Form of form 1 ranitidine NZ272054A(en) * 1994-05-13 1996-05-28 Ranbaxy Lab Ltd

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