What is tolbutamide used for?

What is tolbutamide used for?

Tolbutamide is used to treat high blood sugar levels caused by a type of diabetes mellitus (sugar diabetes) called type 2 diabetes. In type 2 diabetes, your body does not work properly to store excess sugar and the sugar remains in your bloodstream.

What happens when tolbutamide is given with sulfonamides?

This gives a theoretical basis for being careful when tolbutamide and sulfonamides are co-administered. Hypoglycemia, often during the first hours of combining the two drugs, is the result of an important interaction between sulfonylureas and sulfonamides [211–214].

Is tolbutamide an insulin?

Tolbutamide is in a class of medications called sulfonylureas. Tolbutamide lowers blood sugar by causing the pancreas to produce insulin (a natural substance that is needed to break down sugar in the body) and helping the body use insulin efficiently.

How do you increase tolbutamide absorption?

Tolbutamide is detectable in plasma 30-60 minutes following oral administration of a single dose with peak plasma concentrations occurring within 3-5 hours. Absorption is unaltered if taken with food but is increased with high pH. Approximately 95% bound to plasma proteins.

Does tolbutamide cause weight gain?

Stomach upset/fullness, nausea, headache, and weight gain may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

What is the side effect of tolbutamide?

Tolbutamide side effects severe skin rash, redness, or itching; pale skin, easy bruising or bleeding; fever, chills, sore throat, mouth sores; or. low levels of sodium in the body–headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady.

What type of drug is tolbutamide?

SulfonylureaTolbutamide / ClassificationSulfonylureas are a class of organic compounds used in medicine and agriculture, for example as antidiabetic drugs widely used in the management of diabetes mellitus type 2. They act by increasing insulin release from the beta cells in the pancreas. Wikipedia

Is tolbutamide an oral hypoglycemic agent?

Tolbutamide is a first-generation potassium channel blocker, sulfonylurea oral hypoglycemic medication. This drug may be used in the management of type 2 diabetes if diet alone is not effective. Tolbutamide stimulates the secretion of insulin by the pancreas.

What is the drawback of tolbutamide?

Tell your doctor right away if you have any serious side effects, including: dark urine, easy bleeding/bruising, persistent nausea, severe stomach/abdominal pain, signs of infection (such as persistent sore throat, fever), yellowing eyes/skin. This medication can cause low blood sugar (hypoglycemia).

Can tolbutamide cause hypoglycemia?

This medication may cause low blood sugar (hypoglycemia). Symptoms of low blood sugar are weakness, dizziness, hunger, sweating, trembling, blurred vision, walking unsteadily or fast heartbeat.

What is brand name of tolbutamide drug?

tolbutamide systemic Brand names: Orinase, Tol-Tab. Drug class(es): sulfonylureas. Tolbutamide systemic is used in the treatment of: Diabetes, Type 2.

What’s the side effects of glipizide?

Glipizide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• diarrhea.
• gas.
• feeling jittery.
• dizziness.
• uncontrollable shaking of a part of the body.
• red or itchy skin.
• rash.
• hives.