What is the mode of action of esomeprazole?

What is the mode of action of esomeprazole?

Esomeprazole works by binding irreversibly to the H+/K+ ATPase in the proton pump. Because the proton pump is the final pathway for secretion of hydrochloric acid by the parietal cells in the stomach, its inhibition dramatically decreases the secretion of hydrochloric acid into the stomach and alters gastric pH.

What is the structural formula of omeprazole?

C17H19N3O3SOmeprazole / Formula

What functional groups are in esomeprazole?

Esomeprazole is a 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole that has S configuration at the sulfur atom.

Which ring is present in omeprazole?

Physiochemical Properties

4 Solubility Very slightly soluble in water; freely soluble in ethanol; slightly soluble in acetone
5 Octanol/water partition coefficient 2.23
5 Presence of ring Imidazole, pyridine
6 Number of chiral centers Not present

What is esomeprazole used for?

Esomeprazole is used to treat certain stomach and esophagus problems (such as acid reflux, ulcers). It works by decreasing the amount of acid your stomach makes. It relieves symptoms such as heartburn, difficulty swallowing, and persistent cough.

What is the indication of esomeprazole?

Esomeprazole is indicated for the treatment of acid-reflux disorders including healing and maintenance of erosive esophagitis, and symptomatic gastroesophageal reflux disease (GERD), peptic ulcer disease, H.

What is the Iupac name of omeprazole?

Systematic (IUPAC) name
5-methoxy-2-[(4-methoxy-3,5-dimethyl- pyridin-2-yl)methylsulfinyl]-3H-benzimidazole
CAS number 73590-58-6

How is omeprazole different from esomeprazole?

Compared to omeprazole 20 mg, esomeprazole 40 mg provides greater acid control in patients with GERD and keeps stomach pH at higher than 4 for a longer period of time (higher pH = less acidity = less pain). What about esomeprazole 40 mg vs. omeprazole 40 mg?

How is esomeprazole synthesized?

A highly efficient synthesis of esomeprazole has been developed [47] based on the Kagan modification [48] of the Sharpless reagent. The synthesis, which is based on a titanium and chiral tartrate diester-mediated asymmetric oxidation of the corresponding prochiral sulphide, is suitable for large-scale production.

Is esomeprazole the same as omeprazole?

Omeprazole (Prilosec) and esomeprazole (Nexium) are similar drugs. However, there are minor differences in their chemical makeup. Prilosec contains two isomers of the drug omeprazole, while Nexium only contains one isomer.

Can I take esomeprazole every day?

If it has been prescribed for you, you may only take it for a few weeks or months, depending on your condition. Sometimes your doctor may advise you to take it for longer, even many years. Your doctor may suggest taking esomeprazole only when you have symptoms. This means you will not have to take it every day.

Can I take esomeprazole at night?

Night-time acid inhibition was improved when esomeprazole 40 mg od was administered before dinner or at bedtime vs. before-breakfast dosing (P < 0.05). Conclusion: Varying the dose and timing of esomeprazole administration may provide acid inhibition appropriate for the symptom pattern of individual patients with GERD.

How long do esomeprazole sodium solutions last?

Physical and chemical stability of esomeprazole sodium solutions Esomeprazole 0.4 and 0.8 mg/mL as the sodium salt in the infusion solutions tested is chemically and physically stable for at least 2 days at room temperature and 5 days under refrigeration.

What is the molecular weight of esomeprazole sodium?

Esomeprazole Sodium PubChem CID 10959536 Synonyms OMEPRAZOLE SODIUM Esomeprazole Sodium H Molecular Weight 367.4 Parent Compound CID 4594 (Omeprazole) Component Compounds CID 5360545 (Sodium) CID 4594 (Omeprazol

What is omeprazole sodium used for?

Omeprazole sodium is a member of benzimidazoles and a sulfoxide. A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME.

Esomeprazole: a review of its use in the management of gastric acid-related diseases in adults

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