What is recombinant CSF used for?

What is recombinant CSF used for?

The U.S. Food and Drug Administration (FDA) has approved the use of rG-CSF as long-term treatment to reduce the incidence and duration of sequelae of neutropenia (e.g., fever, infections, oropharyngeal ulcers) in symptomatic patients with congenital neutropenia, cyclic neutropenia, or idiopathic neutropenia.

What is recombinant G-CSF?

Recombinant Human G-CSF is purified E. coli expressed recombinant human granulocyte colony stimulating factor (G-CSF). Granulocyte CSF is produced by monocytes and fibroblasts. It stimulates granulocyte colony formation, activates neutrophils and differentiates certain myeloid leukemic cells.

What is G-CSF used for?

G-CSF (granulocyte-colony stimulating factor) is a type of protein called a growth factor. It is used to help your body make more white blood cells.

Is G-CSF a biologic?

What to know about granulocyte colony stimulating factor (G-CSF) Granulocyte colony stimulating factor (G-CSF) is a class of biological medication that doctors prescribe for people who need to boost their white blood cell count. Doctors refer to low blood cell levels as neutropenia.

Is G-CSF the same as filgrastim?

Granulocyte – colony stimulating factor (G-CSF) is another name for filgrastim. In some cases, health care professionals may use the trade name Neupogen, Granix or Zarxio when referring to the generic drug name filgrastim.

How long does it take for G-CSF to work?

This usually takes 5 to 7 days, although it can be longer. If you are having G-CSF before a stem cell transplant, you usually have your first dose 4 to 6 days before your stem cells are going to be collected.

What is G-CSF prophylaxis?

Primary prophylactic G-CSF (PPG) is often used to decrease incidence of FN in patients at high risk. Due to the potential for G-CSF to stimulate neutrophil precursors at the same time as myelosuppression from chemotherapy, it is recommended that G-C SF be administered 24 hours after chemo administration.

Can G-CSF cause leukemia?

Abstract. A large majority of allogeneic hematopoietic stem cell donations are achieved using granulocyte-colony stimulating factor (G-CSF). G-CSF use has been associated with later development of myelodysplastic syndromes/acute myelogenous leukemia (MDS/AML) in several clinical circumstances.

Is there an alternative to filgrastim?

For a large healthcare system, the arrival of a cheaper alternative to filgrastim prompted the conversion to using tbo-filgrastim as the preferrred granulocyte-colony stimulating factor. The results were shared in a study published by the Journal of Managed Care & Specialty Pharmacy.

What is the most common side effect of G-CSF?

What side effects may I notice from receiving this medicine?

• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue.
• back pain.
• dizziness or feeling faint.
• fever.
• pain, redness, or irritation at site where injected.
• pinpoint red spots on the skin.
• shortness of breath or breathing problems.

When should I stop G-CSF?

The manufacturer recommends that the first dose of filgrastim be given no sooner than 24 hours after chemotherapy. Your doctor will discontinue therapy with filgrastim when your white blood cell count has reached acceptable levels.

How long does G-CSF stay in your system?

You can also take ibuprofen up until 24 hours before your donation (which means on days 1-3 of G-CCSF, but not on the 4th day). You must not take aspirin; this is due to the fact it can stay in the system and affect platelet function for 7 days).

What is GCSF human recombinant?

Granulocyte Colony Stimulating Factor Human Recombinant produced in E.coli is a single, non-glycosylated, polypeptide chain containing 175 amino acids and having a molecular mass of 18.8 KD. GCSF is purified by proprietary chromatographic techniques.

Which CSF induces granulocytes?

This csf induces granulocytes. Granulocyte Colony Stimulating Factor Human Recombinant produced in E.coli is a single, non-glycosylated, polypeptide chain containing 175 amino acids and having a molecular mass of 18.8 KD. GCSF is purified by proprietary chromatographic techniques.

How to purify rhG-CSF without isopropyl?

The new system for rhG-CSF purification was performed using not only temperature shift strategy without isopropyl-l-thio-β-d-galactoside (IPTG) induction but also the purification method by a single step of prep-HPLC after the pH precipitation of the refolded samples.

Is purified rhG-CSF similar to the who 2 nd international standard?

The result of biological activity indicated that purified rhG-CSF has a similar profile to the World Health Organization (WHO) 2 nd International Standard for G-CSF.