What is Paterson-Kelly syndrome?
(PA-ter-sun-KEH-lee SIN-drome) A disorder marked by anemia caused by iron deficiency, and a web-like growth of membranes in the throat that makes swallowing difficult. Having Paterson-Kelly syndrome may increase the risk of developing esophageal cancer. Also called Plummer-Vinson syndrome and sideropenic dysphagia.
Which indicate risks of Plummer-Vinson syndrome?
Plummer-Vinson syndrome is one of the risk factors for developing squamous cell carcinoma of the oral cavity, esophagus, and hypopharynx. Esophageal squamous cell carcinoma risk is also increased; therefore, it is considered a premalignant condition.
What happens in Plummer-Vinson syndrome?
Plummer-Vinson syndrome is a condition that can occur in people with long-term (chronic) iron deficiency anemia. People with this condition have problems swallowing due to small, thin growths of tissue that partially block the upper food pipe (esophagus).
Is Plummer-Vinson syndrome curable?
Plummer-Vinson syndrome can be treated effectively with iron supplementation and mechanical dilation. In case of significant obstruction of the esophageal lumen by esophageal web and persistent dysphagia despite iron supplementation, rupture and dilation of the web are necessary.
Is Plummer-Vinson syndrome premalignant?
The syndrome is considered to be a precancerous condition because squamous cell carcinoma of hypopharynx, upper esophagus, or oral cavity takes place in 10% of these patients.
Is Plummer-Vinson syndrome congenital?
A syndrome of DYSPHAGIA with IRON-DEFICIENCY ANEMIA that is due to congenital anomalies in the ESOPHAGUS (such as cervical esophageal webs).
How is Plummer-Vinson syndrome diagnosed?
In patients with suspected Plummer-Vinson syndrome (PVS), obtain complete blood cell (CBC) counts, peripheral blood smears, and iron studies (eg, serum iron, total iron-binding capacity [TIBC], ferritin, saturation percentage) to confirm iron deficiency, with or without hypochromic microcytic anemia.
Is Plummer-Vinson rare?
BACKGROUND Plummer-Vinson syndrome is a rare disease that presents with iron-deficiency anemia, dysphagia, and esophageal webs. It usually occurs in middle-aged White women, and it increases the risk for esophageal cancer.
What does odynophagia feel like?
“Odynophagia” is the medical term for painful swallowing. Pain can be felt in your mouth, throat, or esophagus. You may experience painful swallowing when drinking or eating food. Sometimes swallowing difficulties, known as dysphagia, can accompany the pain, but odynophagia is often a condition of its own.
Why is my food sitting in my throat?
Some of the causes of esophageal dysphagia include: Achalasia. When the lower esophageal muscle (sphincter) doesn’t relax properly to let food enter the stomach, it can cause food to come back up into the throat. Muscles in the wall of the esophagus might be weak as well, a condition that tends to worsen over time.
Can being anemic make it hard to swallow?
Difficulty in swallowing or dysphagia is a common symptom. Esophageal webs are an infrequent cause of dysphagia. These have been found to occur in association with iron deficiency anemia (IDA) and dysphagia.