What is EpCAM antibody?
Description: EpCAM (Epithelial cell adhesion molecule, CD326, KSA, TROP1) is a 40 kD cell-surface adhesion molecule participating in homophilic, calcium-independent cell-cell interactions. EpCAM is a type-I transmembrane protein, and is expressed primarily on the basolateral surface of most epithelia.
What is EpCAM a marker for?
Abstract. The epithelial cell adhesion molecule (EpCAM, CD326) is a glycoprotein of ∼40 kd that was originally identified as a marker for carcinoma, attributable to its high expression on rapidly proliferating tumors of epithelial origin.
Is EpCAM an antigen?
EpCAM (epithelial cell adhesion molecule) is a type I transmembrane glycoprotein, which was originally identified as a tumor‑associated antigen due to its high expression level in rapidly growing epithelial tumors.
How does EpCAM cause Lynch syndrome?
EPCAM deletions lead to a transcriptional read-through, silencing MSH29 and are estimated to cause Lynch syndrome in ∼20–25% of patients with MSH2-negative cancers, but no detectable MSH2 germline mutation. This corresponds to ∼2–3% of Lynch syndrome patients.
Is EpCAM a tumor suppressor?
In contrast to its promoting role regarding tumour formation, EpCAM is also described as a tumour suppressive protein. EpCAM was first proposed to function as a cell adhesion molecule since EpCAM is able to mediate homophilic adhesive interactions (14), thereby preventing cell scattering.
What is gene EPCAM?
The EPCAM gene provides instructions for making a protein known as epithelial cellular adhesion molecule (EpCAM). This protein is found in epithelial cells, which are the cells that line the surfaces and cavities of the body.
What is a EPCAM mutation?
The name EPCAM stands for “Epithelial Cell Adhesion Molecule.” EPCAM gene is located on chromosome 2. Mutations in EPCAM cause Lynch syndrome by affecting the nearby MSH2 gene. The MSH2 gene protein plays an important role in repairing DNA damage.
What is EpCAM stain?
EpCAM is a glycosylated, 30- to 40-kDa type I membrane protein. The sequence of the EpCAM molecule predicts the presence of three potential N-linked glycosylation sites. It is composed of 314 amino acids.
How does EPCAM cause Lynch syndrome?
What is EPCAM stain?
What kind of gene is EPCAM?
EPCAM (Epithelial Cell Adhesion Molecule) is a Protein Coding gene. Diseases associated with EPCAM include Diarrhea 5, With Tufting Enteropathy, Congenital and Colorectal Cancer, Hereditary Nonpolyposis, Type 8.
What gene is EpCAM?