What does the STAT3 gene do?
Through its regulation of gene activity, the STAT3 protein is involved in many cellular functions. It helps control cell growth and division (proliferation), cell movement (migration), and the self-destruction of cells (apoptosis). The STAT3 protein is active in tissues throughout the body.
What genes does STAT3 regulate?
STAT3 can directly and indirectly regulate the expression of many genes implicated in survival (survivin, bcl-xl, mcl-1, FLICE-like inhibitory protein), cell-cycle progression (c-fos, c-myc, cyclin D1), invasion (matrix metalloproteinase MMP 2, 9, 14), and angiogenesis (vascular endothelial growth factor, VEGF) [3,4,5.
What genes does STAT3 activate?
Given its ability to regulate both oncogenes and tumor suppressor genes, STAT3 has been reported to promote and inhibit oncogenesis. STAT3 has been shown to induce cancers of the breast [21,22], prostate [11] and skin [23,24].
What is the STAT3 pathway?
STAT3 signaling is a major intrinsic pathway for cancer inflammation because it is often activated in tumor-associated immune and inflammatory cells as well as malignant cells and is capable of inducing a large number of genes that are crucial for inflammation including IL-6, 10, 11, 17, 23, CXCL12, and COX-2 [127].
What does STAT3 stand for?
STAT3 (Signal Transducer And Activator Of Transcription 3) is a Protein Coding gene. Diseases associated with STAT3 include Hyper-Ige Recurrent Infection Syndrome 1, Autosomal Dominant and Autoimmune Disease, Multisystem, Infantile-Onset, 1.
What is a STAT3 inhibitor?
Specific STAT3 direct inhibitors consist of SH2 ligands, including G quartet oligodeoxynucleotides (ODN) and small molecules, they induce cell death in tumor cells in which STAT3 is activated. STAT3 can also be inhibited by decoy ODNs (dODN), which bind STAT3 and induce cell death.
How is STAT3 activated?
STAT3 is activated by several pro-inflammatory cytokines, including interleukin-6 (IL-6)24,25,26, which is a prime target for therapeutic intervention in several inflammatory diseases including rheumatoid arthritis, Still’s disease and giant cell arthritis.
What does STAT3 transcribe?
STAT3 is found in the cytoplasm and is activated in response to stimuli from the cytokines. Activated STAT3 regulates the transcription of genes controlling cell survival and proliferation and regulates the expression of antiapoptotic and immune response genes [128–130].
What chromosome is STAT3 on?
| STAT3 | ||
|---|---|---|
| Location (UCSC) | Chr 17: 42.31 – 42.39 Mb | Chr 11: 100.78 – 100.83 Mb |
| PubMed search | ||
| Wikidata | ||
| View/Edit Human View/Edit Mouse |
How does STAT3 promote resistance to therapy?
Persistent STAT3 activity can also enhance stem cell-like and mesenchymal properties, making obstruction of the pathway through which it signals a potentially attractive therapeutic strategy. In several studies, increasing in number through the last few years, STAT3 has also been implicated in resistance to radiation.