What does HIF-1 alpha do?
HIF-1alpha forms regulatory loop with YAP to coordinate hypoxia-induced adriamycin resistance in acute myeloid leukemia cells. EtaIotaF1alpha, EGR1 and SP1 co-regulate the erythropoietin receptor expression under hypoxia: an essential role in the growth of non-small cell lung cancer cells.
What is HIF transcription factor?
Hypoxia-inducible factor (HIF) transcription factors are master regulators of the cellular response to hypoxia and coordinate a transcriptional program that ensures optimal functional, metabolic, and vascular adaptation to O2 shortages (Semenza, 2011).
Is HIF-1 a gene or a transcription factor?
HIF-1 is a heterodimeric transcription factor consisting of a constitutively expressed β-subunit and an oxygen-regulated α-subunit. The HIF-1α and HIF-1β proteins both contain basic helix-loop-helix motifs that bind DNA and cause subunit dimerization [7,8,9].
What genes does HIF regulate?
Per its role in mediating acute responses, HIF1A regulates the activation of glycolytic genes, thereby allowing cells to survive under conditions of decreased oxygen by switching the metabolic scheme from one of oxidative phosphorylation to anaerobic glycolysis.
Where is HIF 1a expressed?
In hemangioblastoma, HIF1A expression is found in most cells sampled from the well-vascularized tumor. Although in both renal carcinoma and hemangioblastoma, the von Hippel-Lindau gene is inactivated, HIF1A is still expressed at high levels.
What is the role of HIF?
HIF is a transcription factor that plays an essential role in the cellular response to low oxygen, orchestrating a metabolic switch that allows cells to survive in this environment. In immunity, infected and inflamed tissues are often hypoxic, and HIF helps immune cells adapt.
How does HIF increase performance?
The target genes of HIF-1 increase oxygen transport through mechanisms such as erythropoietin-mediated erythropoiesis and vascular endothelial growth factor-induced angiogenesis and improve tissue function during low oxygen availability through increased expression of glucose transporters and glycolytic enzymes, which …
How does HIF regulate erythropoiesis?
HIF-2 activation (either by hypoxia, pharmacologic means or as a result of mutations) induces renal and hepatic EPO synthesis, which leads to an increase in serum EPO levels and stimulation of erythropoiesis. Iron metabolism is adjusted to match iron demand from increased erythropoiesis.
Where is HIF 1a located?
What is HIF 1bd?
The aryl hydrocarbon receptor nuclear translocator (ARNT, HIF-1β) is a bHLH/PAS family member that acts as a dimerization partner in several distinct signal transduction pathways.
How is HIF-1 activated?
HIF-1α protein synthesis can be induced by many different growth factors and cytokines, such as insulin,54 insulin-like growth factors55 or PDGF. P42/44 mitogen-activated kinase (MAPK) has been implicated in phosphorylation of HIF-1α and activation of MAPK amplifies transcriptional response of HIF.
How does HIF increase oxygen?
HIF activates genes involved in two vital processes. The first is angiogenesis, the formation of blood vessels. The second is the production of hemoglobin, oxygen-carrying red blood cells. Both assist in delivering more oxygen to the places that need it.