What are examples of CCB?
Examples of calcium channel blockers include:
- Amlodipine (Norvasc)
- Diltiazem (Cardizem, Tiazac, others)
- Felodipine.
- Isradipine.
- Nicardipine.
- Nifedipine (Procardia)
- Nisoldipine (Sular)
- Verapamil (Calan SR, Verelan)
What are examples of non dihydropyridine calcium channel blockers?
Calcium Channel Blockers, Non-dihydropyridine
- Calan.
- Calan SR.
- Cardizem.
- Cardizem CD.
- Cardizem LA.
- Cartia XT.
- Covera HS.
- Dilacor.
What are the two types of CCB?
What are the different types? There are two distinct chemical classes of CCBs: the dihydropyridines (such as nifedipine and amlodipine) and the nondihydropyridines (diltiazem and verapamil).
What is the difference in dihydropyridine and non dihydropyridine calcium channel blockers what conditions are they used to treat?
The dihydropyridines are more vascular selective and the non-dihydropyridines are more myocardial selective and tend to reduce the heart rate. Further important differences are between short- and long-acting forms of the calcium channel antagonists.
What can replace amlodipine?
Hydrochlorothiazide.
Is amlodipine a non-dihydropyridine?
Dihydropyridine CCBs (nifedipine and amlodipine) primarily act on vascular smooth muscles. Nondihydropyridine CCBs (verapamil > diltiazem) primarily act on the heart.
Which are the examples of dihydropyridines?
Examples of dihydropyridines include:
- amlodipine (Norvasc)
- felodipine (Plendil)
- isradipine (DynaCirc)
- nicardipine (Cardene)
- nifedipine (Adalat, Procardia)
- nimodipine (Nimotop, Nymalize)
- nisoldipine (Sular)
Is amlodipine a dihydropyridine?
Dihydropyridines — The dihydropyridines, including nifedipine, isradipine, felodipine, nicardipine, nisoldipine, lacidipine, amlodipine, and levamlodipine are potent vasodilators that have little or no negative effect clinically upon cardiac contractility or conduction.
Is amlodipine a DHP CCB?
What is the difference between DHP CCB and non DHP CCB?
Dihydropyridine (DHP) CCBs tend to be more potent vasodilators than non-dihydropyridine (non-DHP) agents, whereas the latter have more marked negative inotropic effects.
Why is amlodipine being recalled?
Citing defective bottles that may not seal appropriately and protect from moisture, Pfizer Inc. is recalling two lots of Caduet (amlodipine besylate/atorvastatin calcium) tablets. The recall was announced in the February 19, 2020, US Food and Drug Administration (FDA) Enforcement Report.
What is the difference between long-acting CCBs and non-DHP CCBs?
If a CCB is being considered in addition to therapy with a beta-adrenergic blocker, the long-acting DHP CCBs are preferred due to the potential for bradycardia or atrioventricular block with a non DHP CCB in combination with a beta-adrenergic blocker.
What is the difference between DHP and non-dihydropyridine CCBs?
Dihydropyridine (DHP) CCBs tend to be more potent vasodilators than non-dihydropyridine (non-DHP) agents, whereas the latter have more marked negative inotropic effects. Both subclasses have a similar capacity to lower BP; however, non-DHPs appear to offer potential advantages in the management of patients with chronic kidney disease
Is there a role for nondihydropyridine calcium channel blockers (CCBs)?
There is evidence to support a role for nondihydropyridine calcium channel blockers (non-DHP CCBs) in such situations, although the data is far less robust than for ACE-Is or ARBs.
Are non-DHP CCBs effective in the treatment of proteinuria?
The literature does suggest non-DHP CCBs can also be effective and are a reasonable option for patients who cannot tolerate or have a contraindication to ACE-Is or ARBs. These treatment options would also likely benefit patients on maximally tolerated ACE-Is or ARBs, but continue to have progression of proteinuria.