Is zuclopenthixol and Flupenthixol the same?
Zuclopenthixol is thought to be more sedating than the related flupentixol, though possibly less likely to induce extrapyramidal symptoms than other typical depots.
What is zuclopenthixol used for?
About zuclopenthixol
| Type of medicine | An antipsychotic medicine |
|---|---|
| Used for | Schizophrenia and other similar mental health disorders in adults |
| Also called | Clopixol® |
| Available as | Tablets, injection and long-acting (‘depot’) injection |
What are the side effects of zuclopenthixol?
Hide table of contents
| Blood and lymphatic system disorders | Thrombocytopenia, neutropenia, leukopenia, agranulocytosis. |
|---|---|
| Nervous system disorders | Tardive dyskinesia, hyperreflexia, dyskinesia, parkinsonism, syncope, ataxia, speech disorder, hypotonia, convulsion, migraine. |
| Neuroleptic malignant syndrome. |
Does Depixol cause weight gain?
Difficulty passing urine. Disturbances of the gut such as constipation, diarrhoea, indigestion, vomiting. Reduced sex drive. Increased appetite and weight gain.
Does Flupentixol cause weight gain?
Having been investigated in numerous studies, flupenthixol was found to be effective and well tolerated by people with schizophrenia. The main side effects are shaking, restlessness or the inability to sit still, a dry mouth and some weight gain.
What does clopixol do to the brain?
Zuclopenthixol blocks the receptors that dopamine acts on and this prevents the overactivity of dopamine in the brain. This helps to control psychotic illness. Zuclopenthixol improves disturbed thoughts, feelings and behaviour in psychotic illness such as schizophrenia.
What type of drug is zuclopenthixol?
Zuclopenthixol is a typical antipsychotic neuroleptic drug of the thioxanthene class. It mainly acts by antagonism of D1 and D2 dopamine receptors.
What class of drug is zuclopenthixol?
Can you overdose on zuclopenthixol?
As Clopixol injections are given to you under the supervision of your doctor, it is very unlikely that you will receive too much. Symptoms of an overdose may include sleepiness, coma, cramps, convulsions, low blood pressure and extremely high or low body temperature.
What is the new drug for schizophrenia?
Paliperidone palmitate (Invega Hafyera; Janssen) has been approved by the FDA as the first and only twice-yearly treatment for adults with schizophrenia, offering the fewest doses per year, according to a press release. The drug is a long-acting atypical antipsychotic injection.
What is the weakest antipsychotic?
Of the atypical antipsychotics, risperidone is the weakest in terms of atypicality criteria.
Is flupenthixol decanoate a useful depot?
Flupenthixol decanoate is one of the most widely used depots in the UK. It is worth investigating the effects of flupenthixol decanoate in comparison with other antipsychotic medications with regards to clinical and non‐clinical outcomes for the benefits of clinicians, patients and managers/policy makers alike.
How is flupentixol used to guide the target dose of haloperidol depot?
The dose of flupentixol can be used to guide the target dose of haloperidol depot. Previous antipsychotic use from the patient’s history may be helpful. Haloperidol is regarded as having a moderate effect on QTc, while flupentixol has a low effect. QTc monitoring may be necessary when switching from flupentixol to haloperidol.
When is oral zuclopenthixol indicated in the treatment of haloperidol toxicity?
Patients should be initially converted to oral zuclopenthixol tablets to exclude allergy. Oral zuclopenthixol may be started while the patient still has significant haloperidol plasma concentrations from the depot. If starting oral zuclopenthixol within a week of the last haloperidol depot, the dose should be approximately 25% of the target dose.
How much zuclopenthixol do you give a patient?
If the patient has not had zuclopenthixol before and oral zuclopenthixol cannot be used, give a test dose of 50 mg of zuclopenthixol depot 5–10 days before the zuclopenthixol depot is to be started. If there are no reactions, give the full dose of zuclopenthixol depot.