How do you administer a reteplase injection?
Reteplase should be administered via an IV line in which no other medication is being simultaneously injected or infused. Do not add any other medications to the injection solution.
When do you give reteplase?
RETAVASE® (reteplase) is a recombinant plasminogen activator which catalyzes the cleavage of endogenous plasminogen to generate plasmin. Plasmin degrades the fibrin matrix of the thrombus, exerting its thrombolytic action. As soon as possible after the onset of STEMI, administer 10 units intravenously over 2 minutes.
What is the difference between reteplase and alteplase?
Reteplase is a second-generation nonglycosylated deletion mutant of alteplase. Reteplase is less fibrin specific than alteplase but has a longer half-life (18 minutes) that enables administration by double-bolus IV injection.
How do you use Thrombolyse with reteplase?
Reteplase is FDA-approved for AMI and is administered as two boluses of 10 U given 30 minutes apart, with each bolus administered over 2 minutes. The result is more convenient administration and faster thrombolysis with reteplase than with alteplase, which is given in a bolus followed by intravenous (IV) infusion.
What is reteplase used for?
Reteplase is used to treat heart attacks by dissolving blood clots that have formed in the blood vessels of the heart. This medicine is used immediately after symptoms of a heart attack occur .
Which thrombolytic is best?
Low-Dose rt-PA Alteplase (rt-PA) is still the most commonly used thrombolytic agent in pulmonary embolism. The approved dose for PTE is infusion of 100 mg in 2 hours. This dose is known to cause major bleeding complications (primarily cerebral hemorrhage), especially in older patients.
What is reteplase injection used for?
Retavase (reteplase) is a thrombolytic drug used to dissolve blood clots used to improve heart function and prevent congestive heart failure or death in people who have had a heart attack.
What class of drug is reteplase?
Reteplase is a thrombolytic (THROM-bo-LIT-ik) drug, sometimes called a “clot-busting” drug.
Is heparin a thrombolytic agent?
Heparin administered intravenously appears to markedly attenuate the thrombin activity associated with thrombolysis and, in patients treated with tissue plasminogen activator (t-PA), prevents early recurrent coronary thrombosis.
When should thrombolytic agents be given?
Ideally, you should receive thrombolytic medicines within the first 30 minutes after arriving at the hospital for treatment. A blood clot can block the arteries to the heart. This can cause a heart attack, when part of the heart muscle dies due to a lack of oxygen being delivered by the blood.
What classification is reteplase?
When can I start heparin after reteplase?
per hour starting after the second reteplase bolus. Heparin should be administered for at least 24 hours, preferably for 48 – 72 hours, aiming to keep aPTT values 1.5 to 2 times normal.