Does clindamycin cover Enterobacteriaceae?
Resistance mechanisms in Gram-negative anaerobes include mutations in the 23S rRNA gene targeted by the drug, alterations in efflux, and erythromycin resistance methylase genes (16). Gram-negative aerobes such as Enterobacteriaceae are impervious to clindamycin and so are inherently resistant (16).
What bacteria is covered by clindamycin?
Like penicillin, it has activity against group A and B streptococci, microaerophilic streptococci and most Streptococcus pneumoniae. It does not, however, have activity against the enterococci. Like cloxacillin and the cephalosporins, clindamycin possesses activity against Staphylococcus aureus.
Can you become resistant to clindamycin?
There are few published clinical failures of clindamycin with emergence of resistance (1, 3, 9, 12, 16). However, there are also reports of successful use of clindamycin in treating patients with D-test-positive isolates (3, 9). We report a clinical failure with documented emergence of resistance.
Does clindamycin treat tooth infection?
Fortunately, tooth infections can usually be treated by a course of antibiotics before they develop into abscesses. One common treatment is clindamycin, an antibiotic that is used by enough patients worldwide to be on the World Health Organization Model List of Essential Medicines.
How common is clindamycin resistance?
Among erythromycin-resistant strains, clindamycin resistance rates dropped from 22% to 10% over 4 years. Before being studied for the possibility of inducible clindamycin resistance, 90% of the strains appeared susceptible to clindamycin among CA-MRSA strains in 2002 (Table 1).
Why can’t you lie down after clindamycin?
You should avoid lying down after taking the antibiotic clindamycin because it may prolong the time it takes for the medication to move through your esophagus into your stomach, potentially irritating your esophagus.
What is the major side effect of clindamycin?
The following reactions have been reported with the use of clindamycin. Gastrointestinal: Abdominal pain, pseudomembranous colitis, esophagitis, nausea, vomiting, and diarrhea (see BOXED WARNING). The onset of pseudomembranous colitis symptoms may occur during or after antibacterial treatment (see WARNINGS).
Why would a dentist prescribe clindamycin?
This antibiotic has been used for many years as prophylactic treatment during dental procedures to prevent endocarditis. However, the spectrum and susceptibility of the bacteria species involved in dental infections indicate that clindamycin would also be an effective treatment option for these conditions.
How long does it take for clindamycin to start working for tooth infection?
How soon will it start working? Clindamycin will start showing its effectiveness within a day or two. If your tooth infection symptoms don’t get any better after taking your medication for a few days, consult your doctor.
What does clindamycin resistance mean?
Inducible resistance to clindamycin was defined as blunting of the clear circular area of no growth around the clindamycin disk on the side adjacent to the erythromycin disk and was designated D-test positive.
Can clindamycin be used to treat nonbacterial infections?
-Because clindamycin therapy has been associated with severe colitis which may end fatally, it should be reserved for serious infections where less toxic antimicrobial agents are inappropriate. It should not be used in patients with nonbacterial infections such as most upper respiratory tract infections.
How does clindamycin work?
Clindamycin works by inhibiting bacterial protein synthesis, which inhibits bacterial growth. It has a bacteriostatic effect which means it stops bacteria from reproducing but doesn’t necessarily kill them. Clindamycin belongs to the class of antibiotics known as lincosamide or lincomycin antibiotics.
What are the precautions when using clindamycin?
Precautions. -Because clindamycin therapy has been associated with severe colitis which may end fatally, it should be reserved for serious infections where less toxic antimicrobial agents are inappropriate. It should not be used in patients with nonbacterial infections such as most upper respiratory tract infections.
What is clindamycin erythromycin used to treat?
Clindamycin continues to be an important agent for the management of infections due to gram-positive cocci and anaerobes. Such pathogens are frequently important in skin, soft tissue, and deep infections of the foot. Erythromycin has an impressive safety record and has retained its activity against …